Chemokines in Behçet's Disease, a Field to Be Explored as a Potential Basis for Therapy; M. Adamantiades-Behçet's disease is a chronic recurrent inflammatory disorder involving the small and large vessels. Die Anwendung topischer Antibiotika nimmt - insbesondere aufgrund der Entwicklung resistenter Bakterienstämme durch ihren Einsatz - kontinuierlich ab. Early identification and treatment is essential. The mechanism can be immune-mediated or thrombotic. The prevalence of the disease evaluated in Berlin-West was 1. Pathogenesis of Adamantiades-Behçet's Disease; C.
The Role of Infectious Agents in the Pathogenesis of Behcet's Disease; F. Akne ist die häufigste dermatologische Erkrankung: Rund 70 - 87 % aller Jugendlichen weisen Akneläsionen auf, 10 - 30 % davon benötigen eine medikamentöse Therapie. Die Datenlage der Therapie der atopischen Dermatitis mit Leukotrienantagonisten ist noch schwach, allerdings zeigt sich wie bei den anderen Erkrankungen des Atopiekreises eine mäßige aber signifikante Besserung der Erkrankung im Vergleich zu Plazebo. While the number of sebaceous glands remains the same during life, sebum levels tend to decrease after menopause in females, whereas no major changes appear until the eighth decade of life in men. The Cochrane Database of Systematic Reviews. In the year 1946, Adamantiades defined thrombophlebitis as the 4th major sign of the disease.
Hormones exert their biological effects on the skin through interaction with high-affinity receptors, such as receptors for peptide hormones, neurotransmitters, steroid hormones and thyroid hormones. Arterial Wall Characteristics In Patients With Adamantiades-Behçet's Disease; A. They often appear late in the progression of the disease but are associated with a poor prognosis. Systemic treatment with antisense oligonucleotides is confounded by the dual problems of potential cytotoxicity of antisense oligonucleotides and carrier molecules such as cationic lipids. The historical picture of the endocrine system as a set of discrete hormone-producing organs has been substituted by organs regarded as organized communities in which the cells emit, receive and coordinate molecular signals from established endocrine organs, other distant sources, their neighbors, and themselves. In this work he also proposed the first diagnostic criteria.
Testosteron, das wichtigste zirkulierende Androgen, wird in den Leydig-Zellen des Hodens und im Ovar synthetisiert und während der Fetalzeit vom plazenta-len Choriongonadotropin stimuliert. Diagnostic criteria, prognostic parameters, assessment of disease activity, and quality of life. All-trans retinoic acid and 9-cis retinoic acid exhibited similar anti-proliferative effects. Reduced androgen levels in aged individuals lead to a slow cellular turnover in the sebaceous glands resulting in hyperplasia of the facial sebaceous glands in advanced age. Adamantiades-Behcet's Disease And Elevated Intracranial Pressure In A 12 Year Old Turkish Girl; U.
With the help of morphologic studies and using Oil Red detection of cellular lipids, cell enlargement, accumulation of lipid droplets in the cytoplasm, and nuclear fragmentation could be observed under treatment with arachidonic acid. . Pharyngial swab: beta-haemolytic streptococci of group A. Retinoids can exhibit agonistic activity but also be neutral antagonists and inverse agonists. Adamantiades-Behçet's Disease And Elevated Intracranial Pressure In A 12 Year Old Turkish Girl; U.
Complete blood cell count and routine serum chemistry were within normal limits, with the exception of erythrocyte sedimentation rates of 18 and 36 mm in the first and second hour, respectively, and a C-reactive protein level of 8. In the two other subjects, characteristic subepidermal lining with granulocytes was observed. Low dose prednisolone is only effective in late-onset congenital adrenal hyperplasia and dopamine agonists only in hyperprolactinemia. In addition, the human skin is able to metabolize hormones and to activate and inactivate them. Comparison of Proteome Map Between Sera of Patients with Behçet's Disease and Controls; Kwang-Hoon Lee, et al. In countries with several ethnic populations, including of Turkmen and Mongol descents, the latter are mainly affected. Measuring Health Related Quality of Life.
In addition to spontaneous single tumors, sebaceous gland carcinomas have been reported in immune-suppressed transplant recipients azathiorpine, cisplatin, cyclosporine A and in association with the Muir-Torre syndrome. Arterial Wall Characteristics In Patients With Adamantiades-Behçet's Disease; A. The histology of a skin lesion revealed a florid leukocytoclastic vasculitis at the upper and middle dermal vessels. Thus, cationic lipids are useful for delivery of antisense oligonucleotides into skin cells in vitro and may be used for topical application on animal and human skin. Cells of the Vitreous Body in Behçet's Disease; T. Linked intrinsic and extrinsic factors are thought to contribute to the development of the disease, which probably occurs by environmental triggering of a genetically determined disorder. Testosteron gelangt über den Blutweg in die Talgdrüsen.
Kortikosteroide werden bei der Therapie der Acne fulminans, niedrig dosiert auch bei der Behandlung von Patienten mit adrenalem Hypergonadismus eingesetzt. During the 5-year-follow-up, recurrent bacterial infections did not induce relapses of the disease, whereas the hepatitis B infection was seroconverted. At last, human skin produces hormones which are released in the circulation and are important for functions of the entire organism, such as sex hormones, especially in aged individuals, and insulin-like growth factor-binding proteins. The Prevalence Of Headache In Behcet's Syndrome; D. Immunopathogenesis and Prevention of Uveitis with the Behçet's Disease-Specific Peptide Linked to Cholera Toxin B; T. Cells of the Vitreous Body in Behcet's Disease; T. Gestagene oder Östrogene jeweils als Monotherapie, Spironolacton, Flutamid, Gonadotropin-Releasing-Hormone-Antagonisten und Hemmer des peripheren Androgenmetabolismus werden nach dem heutigen Kenntnisstand nicht empfohlen.
Fluorescein Angiography and Optical Coherence Tomography in Ocular Behcet's Disease; L. In addition to Adamantiades-Behçet's disease, Adamantiades described the interstitial keratitis in trachomatic patients to be a bacterial infection and classified the epidemic idiopathic hemeralopia. Among patients with ocular Behçet's disease funduscopic findings of optic atrophy, and optic disc paleness have been identified with a frequency of 17. Lack of or only few desmosomal areas were observed. The technique has several advantages and, especially in the treatment of keloids and hypertrophic scars, it provides good therapeutic and cosmetic results with few contraindications and a low incidence of complications Zouboulis et al. A Historical Review of Adamantiades-Behçet's Disease; C.
Endothelial activation leading to a chronic local inflammation process together with platelet and serum factors enhance coagulation and thrombosis. Other organs are not commonly involved. Both treatments were well tolerated. New, more effective and less toxic retinoids, alone or in combination with other drugs and new delivery systems may provide therapeutic solutions for benign and malignant proliferative skin diseases, such as psoriasis and non-melanoma tumors, cancer chemoprevention and differentiation therapy. A Historical Review of Adamantiades-Behcet's Disease; C.